Madison Arza Kennedy
Madison Kennedy is a Ph.D. candidate at the University of Washington, Seattle in the Biological Physics, Structure and Design (BPSD) program. In 2018, she was awarded the prestigious National Science Foundation Graduate Research Fellowship (NSF GRFP) to fund her research and continued education. She is currently pursuing her thesis research in the lab of Dr. Barry Stoddard at the Fred Hutchinson Cancer Center studying the restriction endonuclease PaqCI and de novo designed proteins.
Madison graduated with a B.S. in Chemistry (emphasis Biochemistry) and a minor in Biological Anthropology in May 2018 from San Diego State University (SDSU). She spent three years of her undergraduate career in the Molecular Mechanisms of Disease Laboratory of Dr. Christal Sohl studying the enzymes Isocitrate Dehydrogenase 1 & 2 (IDH1 & IDH2) as well as the kinase Tie2/TEK. Madison was honored to become a National Institute of Health Maximizing Access to Research Careers (NIH MARC) Fellow in 2016 which funded her research and academics for the final two years of her undergraduate degree. |
The Stoddard Lab, 2019
SDSU Maximizing Access to Research Careers (MARC), 2016
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Publications
Kennedy, M.A., Hosford, C., Luyten, Y., Morgan, R.D., and Stoddard, B.L. “Structures, activity, and mechanism of tetrameric Type IIS restriction endonuclease PaqCI” manuscript in preparation (intended submission fall 2022).
Hicks, D.R., Kennedy, M.A. Thompson, K., Michelle DeWitt, Coventry, B., Kang, A. Y-S., Bera, A, Brunette, T.J.,Sankaran, B., Stoddard, B.L. and Baker, D. (2022) “De novo design of protein homodimers containing tunable symmetric protein pockets” Proceedings of the National Academy of Sciences. 119 (30). doi: 10.1073/pnas.2113400119
Hallinan, J.P., Doyle, L.A., Shen, B.W., Gewe, M.M., Takushi, B., Kennedy, M.A., Friend, D., Roberts, J.M., Bradley, P., Stoddard, B.L. (2021) Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces. Communications Biology. 4 (1240). doi: 10.1038/s42003-021-02766-y
Lynch, E.M., DiMattia, M.A., Albanese, S., van Zundert, G.C.P., Hansen, J.M., Quispe, J.D., Kennedy, M.A., Verras, A., Borrelli, K., Toms, A.V., Kaila, N., Kreutter, K.D., McElwee, J.J., Kollman, J.M. (2021) Structural basis for isoform-specific inhibition of human CTPS1. Proceedings of the National Academy of Sciences. 118 (40). doi: 10.1073/pnas.2107968118
Kennedy, M.A., Xu, Z., Wu, Y., and Sohl, C.D. (2019) A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhance cooperativity. Biochemical and Biophysical Research Communications. 509 (4): 898‑902. doi: 10.1016/j.bbrc.2019.01.020
Matteo, D.A., Grunseth, A.J., Gonzalez, E.R., Anselmo,S.L., Kennedy, M.A., Moman, P., Scott, D.A., Hoang, A., and Sohl, C.D. (2017) Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency. The Journal of Biological Chemistry. 292 (19):7971‑7983. doi: 10.1074/jbc.M117.776179
Hicks, D.R., Kennedy, M.A. Thompson, K., Michelle DeWitt, Coventry, B., Kang, A. Y-S., Bera, A, Brunette, T.J.,Sankaran, B., Stoddard, B.L. and Baker, D. (2022) “De novo design of protein homodimers containing tunable symmetric protein pockets” Proceedings of the National Academy of Sciences. 119 (30). doi: 10.1073/pnas.2113400119
Hallinan, J.P., Doyle, L.A., Shen, B.W., Gewe, M.M., Takushi, B., Kennedy, M.A., Friend, D., Roberts, J.M., Bradley, P., Stoddard, B.L. (2021) Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces. Communications Biology. 4 (1240). doi: 10.1038/s42003-021-02766-y
Lynch, E.M., DiMattia, M.A., Albanese, S., van Zundert, G.C.P., Hansen, J.M., Quispe, J.D., Kennedy, M.A., Verras, A., Borrelli, K., Toms, A.V., Kaila, N., Kreutter, K.D., McElwee, J.J., Kollman, J.M. (2021) Structural basis for isoform-specific inhibition of human CTPS1. Proceedings of the National Academy of Sciences. 118 (40). doi: 10.1073/pnas.2107968118
Kennedy, M.A., Xu, Z., Wu, Y., and Sohl, C.D. (2019) A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhance cooperativity. Biochemical and Biophysical Research Communications. 509 (4): 898‑902. doi: 10.1016/j.bbrc.2019.01.020
Matteo, D.A., Grunseth, A.J., Gonzalez, E.R., Anselmo,S.L., Kennedy, M.A., Moman, P., Scott, D.A., Hoang, A., and Sohl, C.D. (2017) Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency. The Journal of Biological Chemistry. 292 (19):7971‑7983. doi: 10.1074/jbc.M117.776179